THE ROLE OF VITAMIN D IN THE PATHOGENESIS OF ATOPIC DERMATITIS

Abstract

Atopic dermatitis is a multifactorial, genetically determined chronic inflammatory skin disease characterized by impaired epidermal barrier function. Worldwide, it affects approximately 20% of children and up to 10% of adults. The aim of this article was to study the role of vitamin D in the pathogenesis of atopic dermatitis. Vitamin D plays a crucial role not only in maintaining calcium and phosphate homeostasis but also in regulating skin homeostasis and immune responses.

Vitamin D primarily influences the pathogenesis of atopic dermatitis through the vitamin D receptor, which is expressed on various immune cells, including keratinocytes, T cells, and monocytes. The interaction between vitamin D and the vitamin D receptor modulates the transcription of genes involved in immune regulation and skin homeostasis.